GLP-1 antagonists are a class of medications that mainly manage blood sugar levels in people with Type 2 diabetes. Some GLP-1 antagonists can also help treat obesity.
When a person starts to lose weight on a GLP-1 weight loss medication, it can happen very fast. However, as they lose fat, they could also be losing essential lean muscle mass, which can harm their metabolism and blood sugar levels. This will ultimately work against weight loss efforts and can even negatively affect bone health.
Protein is the building block of muscle. Getting enough is crucial for preventing muscle loss, especially when consuming fewer calories. When you consume enough protein, you are more likely to retain and even build muscle. However, when you don’t have enough protein, your body will cannibalize some of your muscle mass for energy.
A 2024 review study that made diet recommendations for GLP-1 patients based on the latest research recommends at least 60 grams of protein a day. It is suggested to aim for 20 to 40 grams of protein at every meal.
Most people who are on GLP-1 medications experience at least one side effect. The side effects are worse just after starting and in the days after increasing the dose. Fortunately, there are ways to combat those side effects, including:
- Make every meal count
- Schedule your meals
- Make protein a priority
- Aim for 64 ounces of fluid a day, plus electrolytes
- Avoid fatty and greasy foods
- Steer clear of sugary foods, alcohol, and refined carbs
- Maintain muscle with resistance training
- Eat smaller portions more frequently
- Add fiber to your diet
- Talk to your doctor if you are having side effects
For more information about the Bariatric Surgery Services at Flushing Hospital or procedures performed by our doctors, please call 718-408-6977 or 718-670-8908.
All content of this newsletter is intended for general information purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Please consult a medical professional before adopting any of the suggestions on this page. You must never disregard professional medical advice or delay seeking medical treatment based upon any content of this newsletter. PROMPTLY CONSULT YOUR PHYSICIAN OR CALL 911 IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY.


Weight loss specialists, Sanjeev Rajpal MD, Darshak Shah MD and Noman Khan MD are all excited that Flushing is one of the only hospitals in the area to offer our patients the revolutionary, Obalon weight loss system. Obalon is the first and only non-surgical, and completely non-invasive weight loss treatment option approved by the Food and Drug Administration (FDA).